Airway Responses to NO2 and Allergen in Asthmatics
نویسنده
چکیده
4 LIST OF ORIGINAL PAPERS 5 ABBREVIATIONS 8 INTRODUCTION 9 AIR POLLUTANTS 9 NO2 and its chemical properties 10 Pulmonary deposition of NO2 11 Health effects of air pollutants 11 Epidemiologic studies of health effects of NO2 12 Controlled human exposure studies in healthy subjects 12 Controlled human exposure studies in asthmatics 13 ALLERGIC AIRWAY DISEASE 14 Rhinitis and asthma 14 Combined airway disease 15 Allergic inflammation 15 Monitoring of inflammation in allergic airway disease 16 EFFECTS OF NO2 AND ALLERGEN IN CONTROLLED HUMAN EXPOSURE STUDIES 17 AIMS 18 SUBJECTS AND METHODS 19 Subjects and study design 19 Exposure chamber and exposure data 21 Individual ambient NO2 measurements 22 Bronchial allergen challenge 22 Nasal allergen challenge 23 Spirometry and body pletysmography 24 Bronchoscopy 24 BW and BAL analyses 25 Sputum induction 25 Sputum processing and analyses 25 Blood samples, differential cell counts, inflammatory markers 26 Nasal lavage 26 Symptoms 26
منابع مشابه
The effect of exposure to ozone and nitrogen dioxide on the airway response of atopic asthmatics to inhaled allergen: dose- and time-dependent effects.
Eleven mild atopic asthmatic patients were exposed for 6 h, in randomized order, to air, 100 ppb O3, 200 ppb NO2, and 100 ppb O3 + 200 ppb NO2, followed immediately by bronchial allergen challenge. Subsequently 10 of these patients were exposed for 3 h to air, 200 ppb O3, 400 ppb NO2, and 200 ppb O3 + 400 ppb NO2, followed immediately by bronchial allergen challenge. All exposures were carried ...
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BACKGROUND Nitrogen dioxide (NO2), a ubiquitous atmospheric pollutant, may enhance the asthmatic response to allergens through eosinophilic activation in the airways. However, the effect of NO2 on inflammation without allergen exposure is poorly studied. OBJECTIVES We investigated whether repeated peaks of NO2, at various realistic concentrations, induce changes in airway inflammation in asth...
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Repeated low-dose allergen challenge increases airway hyperresponsiveness in atopic asthmatics. However, it is not known whether low-dose allergen challenge increases airway inflammation. Eight atopic asthmatics were enrolled in a controlled, cross-over study to evaluate the effect and time course of repeated low-dose allergen challenge on airway inflammation and hyperresponsiveness. The dose o...
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